Polyclonal antibody to CARD6 (CARD2)
Produktgrößen
50 µl
£396,00
20-1038-50UL
Über dieses Produkt
- SKU:
- 20-1038
- Zusätzliche Namen:
- CARD6
- Klonalität:
- Polyclonal
- Weitere Details:
- CARDs (caspase recruitment domain) are homotypic protein-protein interaction motifs belonging to the death domain (DD)-fold superfamily (reviewed in Werts et al; 2006). Homotypic interactions among CARD-containing proteins can occur with various proteins; including the inactive zymogen forms of caspases which have N-terminal pro-domains containing complementary CARDs. These interactions can result in the formation of multiprotein complexes; leading to protease cleavage and caspase activation. Most proteins containing a CARD are involved in signal transduction pathways that regulate apoptosis; adaptive immunity; or innate immunity including NF-kB activation and inflammation. There is a large number of CARD containing proteins; and the unique function of each remains to be fully elucidated. CARD6 is a CARD-containing protein with a domain structure that doesn't appear to be shared by any other protein (Stehlik et al; 2003). CARD6 has been found to associate with microtubules; and is structurally and potentially functionally related to the superfamily of interferon (INF)-inducible GTPases (Dufner; 2006). INF-inducible GTPases belong to a growing family of host defense proteins that confer cell immunity. Specifically; is thought that CARD6 may act as a pattern recognition receptor that combats pathogens in a cell-autonomous manner. CARD6 is a 1037 amino acid protein; and CINCIN1 is 311 amino acid splice variant of CARD6. This antibody recognizes both CARD6 and CINCIN1.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of CARD6 (CARD2) protein (amino acids 156-173 RETALSARKNEKEYDTPE) was used as the immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:20-1038.jpg