Polyclonal antibody to m Bax
Produktgrößen
50 µl
£396,00
20-1024-50UL
Über dieses Produkt
- SKU:
- 20-1024
- Zusätzliche Namen:
- Apoptosis regulator BAX
- Klonalität:
- Polyclonal
- Weitere Details:
- The Bcl-2 families of apoptosis-related genes plays central roles in regulating apoptotic pathways. Regulation of cell death through apoptosis is critical for the maintenance of homeostasis; defense against infectious agents; and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals; the family consists of both prosurvival (antiapoptotic) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains; for example: 1) Prosurvival: Bcl-2; Bcl-XL; Bcl-W; A1; and Mcl-1 2) Proapoptotic (multidomain): Bax; Bak; and Bok. 3) BH3-only (proapoptotic): Bad; Bcl-XS; Bid; Bik; Bim; Blk; Bmf; Bnip; Noxa; and Puma. This antibody reacts with mouse; rat and gerbil Bax isoforms. Mouse and rat Bax alpha are 192 amino acid proteins.Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases; autoimmune diseases; AIDs; Downs syndrome; cardiovascular diseases; diabetes; glomerulonephritis; and muscular dystrophy.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A Full length recombinant protein of mouse Bax was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
