Polyclonal antibody to Bad
Produktgrößen
50 µl
£396,00
20-1010-50UL
Über dieses Produkt
- SKU:
- 20-1010
- Zusätzliche Namen:
- BAD||BBC6||BCL2L8
- Klonalität:
- Polyclonal
- Weitere Details:
- The Bcl-2 families of apoptosis-related genes plays central roles in regulating apoptotic pathways. Regulation of cell death through apoptosis is critical for the maintenance of homeostasis; defense against infectious agents; and normal development. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains; for example: 1) Prosurvival: Bcl-2; Bcl-XL; Bcl-W; A1; and Mcl-1 2) Proapoptotic (multidomain): Bax; Bak; and Bok. 3) BH3-only (proapoptotic): Bad; Bcl-XS; Bid; Bik; Bim; Blk; Bmf; Bnip; Noxa; and Puma. Human Bad is a 168 amino acid protein. The prosurvival members inhibit cells from undergoing apoptosis; whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical prosurvival family members have all four BH domains (1-4); whereas proapoptotic (multidomain) members have BH1; 2 and 3 domains and BH3-only members have only the BH3 domain. Overall; the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases; autoimmune diseases; AIDs; Downs syndrome; cardiovascular diseases; diabetes; glomerulonephritis; and muscular dystrophy.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A full length recombinant protein of human Bad was used as immunogen
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
