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Antikörper

Polyclonal antibody to APAF-1

Produktgrößen
50 µl
£396,00
20-1004-50UL
Über dieses Produkt
SKU:
20-1004
Zusätzliche Namen:
APAF1||KIAA0413
Klonalität:
Polyclonal
Weitere Details:
Apaf 1 (apoptosis protease-activating factor-1) is a key regulator of the mitochondrial apoptotic pathway; being the central element of the multimeric apoptosome.The apoptosome consists of cytochrome c; procaspase-9 and seven Apaf 1 monomers; and is considered to be core apoptotic machinery that executes mitochondria-dependent apoptosis. Cytochrome c; normally compartmentalized in the mitochorndria; is released into the cytoplasm following apoptotic stimuli. Apaf 1 binds cytochrome c in the cytoplasm and in the presence of dATP/ATP forms the apoptosome. The apoptosome binds procaspase-9 and promotes its autocatalytic activation. Active caspase-9; in turn; activates downstream caspases including 3; 6; and 7 contributing to the proteolytic caspase activation cascade which leads to cell death.
Format:
Sera
Host:
Rabbit
Immunogen:
A full-length recombinant protein of APAF-1 was used as immunogen for this antibody
Isotyp:
Rabbit IgG
Reaktivitäten:
Human, Mouse, Rat
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Polyclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig:2 Formalin-fixed; paraffin-embedded sections from a human brain tumor tissue microarray stained for Apaf 1 expression using 20-1004 at 1:2000. A and B. Tissue microarray overview. A1 and B1; higher magnification of cores from A and B; respectively. Differential expression of Apaf 1 is seen between patient samples. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded tissue sections of human brain tumors stained for Apaf 1 expression using 20-1004 at 1:2000. A. Gemistocytoma (grade II). B. Anaplastic glioma. A high level of Apaf 1 was observed in the gemistocytoma whereas a low level was seen in the more malignant anaplastic glioma. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded tissue sections of human brain tumors stained for Apaf 1 expression using 20-1004 at 1:2000. A. Gemistocytoma (grade II). B. Anaplastic glioma. A high level of Apaf 1 was observed in the gemistocytoma whereas a low level was seen in the more malignant anaplastic glioma. Hematoxylin-eosin counterstain.