BCMA Blocking Peptide
Produktgrößen
50 µg
£330,00
15-3001-50UG
Über dieses Produkt
- SKU:
- 15-3001
- Zusätzliche Namen:
- B-cell maturation protein; BCM; BCMA; CD269; TNFRSF17
- Weitere Details:
- Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF41-4 and April/TALL-2; respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors; BCMA (for B cell maturation protein); TACI; and BAFF-R; for BAFF were recently identified. BCMA; like TACI; binds BAFF and April. BAFF and its receptors induce B cell development and survival; activate NF-kB and c-jun N-terminal kinase; and are involved in B cell associated autoimmune diseases. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface; BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development; function and regulation. Mouse and human BCMA share 62% amino acid identity.
- Immunogen:
- Peptide sequence of Human BCMA protein is located at (amino acids 169-184) and 16 amino acids near the carboxy terminus of human BCMA.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store this peptide in working aliquots at -20[o]C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Peptides
- Datenblatt des Herstellers:download_pdf.php