Poly(I).Poly(C); HMW
Produktgrößen
1 mg
£166,00
15-1012-1MG
2 mg
£221,00
15-1012-2MG
Über dieses Produkt
- SKU:
- 15-1012
- Zusätzliche Namen:
- Polyinosinic-polycytidylic acid; potassium salt (poly (I:C))
- Weitere Details:
- MW: High molecular weight (>1.5kb). Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA; a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3); melanoma differentiation-associated gene 5 (MDA5); and retinoic acid-inducible gene-I (RIG-I); all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-beta; but can also enhance the expression of pro-apoptotic proteins. Recently; poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex; a novel intracellular signaling complex; thought to induce regulated necrosis; also called 'Necroptosis'.
- Aufreinigung:
- Purity:>=99%
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the product at 4[o]C for short term and at -20[o]C for long-term storage. The product is stable for 2 years at -20[o]C.
- Hersteller:
- Abeomics
- Typ:
- Biomaterials
- Datenblatt des Herstellers:1.jpg