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TLR4/HEK293 Stable Cell Line

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1 Vial
£2747,00
14-533ACL-1VIAL
Über dieses Produkt
SKU:
14-533ACL
Weitere Details:
TLR4/HEK293 Stable Cell Line is a stably transfected HEK293 cell line which expresses human Toll-like receptor 4 (TLR4; also designated as CD284). TLR4 mediates immune responses by recognition of lipoplysaccharides (LPS) with the help of LPS-binding protein; CD14 and MD-2. TLR4 stimulation uniquely triggers two signaling pathways named the MyD88-dependent pathway and the TRIF-dependent pathway; which lead to the production of two sets of cytokines such as proinflammatory cytokines and type I interferons/chemokines; respectively. Note that TLR4 in the TLR4/HEK293 stable cell line contains the N-terminal HA tag (Figure 2); which does not interfere with TLR4 activity as confirmed by functional assay (Figure 1). Sequence data: Human TLR4 (accession number NP_612564) MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELN FYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLS HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHN LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFI QPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSA LEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQH LELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCS QSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLI YLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQL EQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH FPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLN ITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSS QDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQH FIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWE DSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Immediately upon receipt; store in liquid nitrogen.
Hersteller:
Abeomics
Typ:
Cells:Cell Lines
Fig-2: Western blot analysis of TLR4 expression in the TLR4/HEK293 cell line. Cell lysates were analyzed by SDS-PAGE followed by Western blotting using anti-HA antibody. Note that TLR4 in the TLR4/HEK293 stable cell line contains the N-terminal HA tag. Control; parental HEK293 cell lysate; TLR4; TLR4/HEK293 cell lysate.
Fig-2: Western blot analysis of TLR4 expression in the TLR4/HEK293 cell line. Cell lysates were analyzed by SDS-PAGE followed by Western blotting using anti-HA antibody. Note that TLR4 in the TLR4/HEK293 stable cell line contains the N-terminal HA tag. Control; parental HEK293 cell lysate; TLR4; TLR4/HEK293 cell lysate.