Anti-SIGLEC7 antibody(DMC475); IgG1 Chimeric mAb
Produktgrößen
10 µg
£490,00
12-9451-10UG
100 µg
£801,00
12-9451-100UG
Über dieses Produkt
- SKU:
- 12-9451
- Zusätzliche Namen:
- AIRM-1; AIRM1; CD328; CDw328; D-siglec; p75; p75:AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2
- translate.label.attr.clone:
- DMC475
- Klonalität:
- Monoclonal
- Weitere Details:
- Description :Anti-SIGLEC7 antibody(DMC475); IgG1 Chimeric mAbPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2;3- and alpha-2;6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside; disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response; may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34 cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB:Swiss-Prot Function]
- Host:
- Rabbit
- Isotyp:
- Rabbit/Human Fc chimeric IgG1
- Aufreinigung:
- Purified from cell culture supernatant by affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg