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Antikörper

Anti-GITR antibody(DM78); Rabbit mAb

Produktgrößen
100 µg
£801,00
12-9252-100UG
Über dieses Produkt
SKU:
12-9252
Zusätzliche Namen:
AITR; TNFRSF18; CD357;
translate.label.attr.clone:
DM78
Klonalität:
Monoclonal
Weitere Details:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation; and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Host:
Rabbit
Aufreinigung:
Purified from cell culture supernatant by affinity chromatography
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C for 12 months (Avoid repeated freezing and thawing)
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2. Expi 293 cell line transfected with irrelevant protein (A) and human GITR (B) were surface stained with Rabbit anti-GITR monoclonal antibody 1µg/ml (clone: DM78) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.
Figure 3. Flow cytometry data of serially titrated Rabbit anti-GITR monoclonal antibody (clone: DM78) on PC3 cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
Figure 4. Affinity ranking of different Rabbit anti-GITR mAb clones by titration of different concentration onto PC3 cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
Figure 4. Affinity ranking of different Rabbit anti-GITR mAb clones by titration of different concentration onto PC3 cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
Figure 5. Flow cytometry analysis of antigen binding of rabbit anti-human GITR mAb. (A) Anti-human GITR mAb does not bind to 293T cells that do not express GITR. (B) A clear peak shift of anti-human GITR mAb was seen compared to the control when incubated with GITR-expressing 8226 cells; indicating strong binding of anti-human GITR mAb to GITR. Antibodies were incubated at 2 µg/mL.