Biotinylated Anti-B4GALT1 antibody(DMC392); IgG1 Chimeric mAb
Produktgrößen
10 µg
£526,00
12-9245B-10UG
100 µg
£1002,00
12-9245B-100UG
Über dieses Produkt
- SKU:
- 12-9245B
- Zusätzliche Namen:
- GGTB2; Beta4Gal-T1; b4Gal-T1; Nal synthase
- translate.label.attr.clone:
- DMC392
- Klonalität:
- Monoclonal
- Weitere Details:
- This gene is one of seven beta-1;4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1;4 linkage to similar acceptor sugars: GlcNAc; Glc; and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins; they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity; the beta4GalTs form four groups: beta4GalT1 and beta4GalT2; beta4GalT3 and beta4GalT4; beta4GalT5 and beta4GalT6; and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity; the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose D-glucose UDP lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts; which differ only at the 5' end; with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound; trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
- Host:
- Rabbit
- Isotyp:
- IgG1
- Aufreinigung:
- Purified from cell culture supernatant by affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php