Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-E6) HRP
Produktgrößen
50 µg
£840,00
12-8477-50UG
Über dieses Produkt
- SKU:
- 12-8477
- Zusätzliche Namen:
- COV2-NP1-E6; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP1-E6
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP1-E6; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore; it is reported to not bind directly to the RNA binding domain or the oligomerization domain of the N protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the causative agent of coronavirus disease 2019 (COVID-19); is an enveloped; single-stranded; positive-sense RNA virus belonging to the Coronaviridae family1. The SARS-CoV-2 genome encodes four essential proteins: the spike (S); envelope (E); membrane (M); and nucleocapsid (N) proteins2. SARS-CoV-2 shares 79.6% identity with the original SARS-CoV2. The N protein is 46 kDa and consists of two highly conserved structural domains; the N-terminal domain (NTD) and C-terminal domain (CTD); connected by a linker region. The NTD and CTD are involved in a couple of primary functions; including RNA binding and self-oligomerization3;4. This results in binding to and packaging of the viral RNA genome into a helical ribonucleoprotein5. The N protein is involved in other critical steps of the viral life cycle; including transcription; replication; and modulating infected cell signaling pathways6;7. The N protein is a suitable candidate for vaccine development and diagnostic assays8 for several reasons. It is abundantly expressed during infection and is highly conserved; sharing 90% amino acid homology with the SARS-CoV N protein9. Furthermore; antibodies9;10 and memory T cells11;12 targeting the N protein are identified in the sera of convalescent COVID-19 patients; demonstrating it as immunogenic. The N protein also suppresses antiviral RNAi; evading the innate immune system13; suggesting its potential value as a targeted therapeutic.
- Isotyp:
- Human IgG1
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This horseradish peroxidase conjugated monoclonal antibody is stable when stored at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php