Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-C5) Biotin
Produktgrößen
50 µg
£771,00
12-8458-50UG
Über dieses Produkt
- SKU:
- 12-8458
- Zusätzliche Namen:
- COV2-NP1-C5; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP1-C5
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP1-C5; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore; it is reported to bind to the RNA binding domain of the N protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 belongs to the Coronaviridae family; and its single-stranded; positive-sense RNA genome shares 79.6% identity with SARS-CoV1. The spike (S); envelope (E); membrane (M); and nucleocapsid proteins (N) are four essential structural proteins of SARS-CoV-22. The 46 kDa N protein is highly conserved and shares 90% homology with SARS-CoV3. Similar to SARS-CoV; SARS-CoV-2 has an N-terminal (NTD) and C-terminal domain (CTD); linked by a linker region. The NTD binds to RNA; while the CTD self-oligomerizes4;5; aiding viral genome packaging into a helical ribonucleoprotein complex6. The N protein also participates in viral transcription; replication; and modulation of cell signaling pathways7;8. Some vaccine and diagnostic assays9 have focused on the N protein as it is highly expressed during infection and activates antibodies3;10 and memory T cells11;12; found in convalescent sera. The N-protein also evades the innate immune system by inhibiting RNAi13; identifying it as a potential therapeutic target.
- Isotyp:
- Human IgG1
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This bioinylated antibody is stable when stored at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php