Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP2-B1)- Purified No Carrier Protein
Produktgrößen
100 µg
£810,00
12-8451-100UG
500 µg
£1222,00
12-8451-500UG
Über dieses Produkt
- SKU:
- 12-8451
- Zusätzliche Namen:
- COV2-NP2-B1; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP2-B1
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP2-B1; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 belongs to the Coronaviridae family; and its single-stranded; positive-sense RNA genome shares 79.6% identity with SARS-CoV1. The spike (S); envelope (E); membrane (M); and nucleocapsid proteins (N) are four essential structural proteins of SARS-CoV-22. The 46 kDa N protein is highly conserved and shares 90% homology with SARS-CoV3. Similar to SARS-CoV; SARS-CoV-2 has an N-terminal (NTD) and C-terminal domain (CTD); linked by a linker region. The NTD binds to RNA; while the CTD self-oligomerizes4;5; aiding viral genome packaging into a helical ribonucleoprotein complex6. The N protein also participates in viral transcription; replication; and modulation of cell signaling pathways7;8. Some vaccine and diagnostic assays9 have focused on the N protein as it is highly expressed during infection and activates antibodies3;10 and memory T cells11;12; found in convalescent sera. The N-protein also evades the innate immune system by inhibiting RNAi13; identifying it as a potential therapeutic target.
- Host:
- Mouse
- Isotyp:
- Human IgG1
- Aufreinigung:
- Purity :>=90% monomer by analytical SEC and SDS-PagePreparation : Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg