Anti-Influenza A; HA (Clone: Flu-5J8) Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8439-250UG
1 mg
£812,00
12-8439-1MG
Über dieses Produkt
- SKU:
- 12-8439
- Zusätzliche Namen:
- Flu
- translate.label.attr.clone:
- Flu-5J8
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Flu-5J8 activity is directed against a conserved H1 epitope adjacent to the receptor binding site domain on the HA globular head. Furthermore; clone Flu-5J8 binds HA using receptor mimicry3. By inserting its HCDR3 into the HA receptor binding site (RBS); Flu-5J8 closely mimics the natural sialoglycan receptor and blocks viral-host interactions. Flu-5J8 contacts the Sb and Ca2 antigenic sites and binds to conserved residues in the RBS (130 loop; 190 helix; and 220 loop) as well as outside the RBS at the 140 loop. Furthermore; EM reconstructions show that Flu-5J8 occupies all three potential binding sites at the HA apex at and around the RBS. Mutations located between the receptor-binding pocket and the Ca2 antigenic site at residues 133A; 137; or 222 eliminate binding. In a lethal challenge in mice; Flu-5J8 protected all animals at the high and medium doses given and reduced lung virus titers relative to the control2. Antigen Distribution: HA is on the viral surface. Background: Hemagglutinin (HA) is a glycoprotein on the Influenza A (IAV) viral surface1. HA consists of two domains: an antigenically variable head and a more conserved stem. There are 18 HA subtypes. Neutralizing antibodies targeting the head domain are typically restricted to within subtype; while antibodies targeting the stem offer broader protection. In contrast; Flu-5J8 targets the HA globular head and offers broad protection2. Flu-5J8 inhibits all 1918 to 1977 H1N1 strains tested plus the pandemic 2009 strain but not the seasonal H1N1 strains from 1999 or 2007.
- Isotyp:
- Human IgG1
- Aufreinigung:
- Purity :>=90% monomer by analytical SEC and SDS-PagePreparation : Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php