Anti-Influenza A; HA (Clone: FluA-20) Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8438-250UG
1 mg
£812,00
12-8438-1MG
Über dieses Produkt
- SKU:
- 12-8438
- Zusätzliche Namen:
- FluA
- translate.label.attr.clone:
- FluA-20
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: FluA-20 activity is directed against a novel epitope at the trimer interface of the hemagglutinin (HA) head domain of most influenza A viruses. Furthermore this antibody binds to HA trimers from a wide array of strains (H1; H2; H3; H4; H5; H6; 2/3 of H7 strains tested; H8; H9; H10; H11; H12; H14; H15) but not H16. Structural studies of FluA-20 with the HA head domain revealed a novel epitope that is mostly buried in the peripheral interface of the native HA trimer on the non-receptor-binding site side of the 220-loop; adjacent to the 90-loop1. Many FluA-20 to HA contacts are centered on Arg229; and alanine mutation of Arg229 abolishes binding. Other mutations; at residues Arg220; Val223 or Pro96; also substantially decrease binding. These results are similar in H1; H3; and H5 strains. The key residues recognized by FluA-20; Pro96; Arg220; Pro221; Val223; and Arg229; are highly conserved across diverse subtypes. Antigen Distribution: HA is on the viral surface. Background: Hemagglutinin (HA) is a glycoprotein on the Influenza A (IAV) viral surface1. HA consists of two domains: an antigenically variable head and a more conserved stem. There are 18 HA subtypes. Neutralizing antibodies targeting the head domain are typically restricted to within subtype; while antibodies targeting the stem offer broader protection. In contrast; FluA-20 is a human antibody that recognizes the HA head domain of nearly all subtypes of IAV with high affinity1.
- Isotyp:
- Human IgG1
- Aufreinigung:
- Purity :>=90% monomer by analytical SEC and SDS-PagePreparation : Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php