Anti-SARS-CoV-1; Spike RBD (Clone COV1-62)-Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8262-250UG
1 mg
£812,00
12-8262-1MG
Über dieses Produkt
- SKU:
- 12-8262
- translate.label.attr.clone:
- COV1-62
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: COV1-62 targets the RBD of the SARS-CoV-1 prefusion spike protein (S2); located on the viral surface. Antigen Distribution: Anti-SARS-CoV-1 recognizes antigens on infected cells; including respiratory epithelial cells. Background: SARS-CoV-1; also known as the Severe Acute Respiratory Syndrome coronavirus; is a zoonotic virus that is believed to have originated from an animal reservoir; possibly horseshoe bats; and transmitted to humans1. This virus primarily affects the respiratory system and can cause symptoms such as muscle pain; headache; fever; cough; dyspnea; and pneumonia1;2. It was the first severe and readily transmissible new disease to emerge in the 21st century; with the capacity to spread globally via international air travel. The COV1-62 monoclonal antibody targets the receptor-binding domain (RBD) of the SARS-CoV-1 spike protein and does not cross-react with the SARS-CoV-2 spike protein. Although it does not block the ACE2 receptor; COV1-62 acts as a neutralizing antibody; indicating it can inhibit viral entry into host cells through a different mechanism. This could involve preventing the spike protein from achieving the necessary conformations for fusion with the host cell membrane. The neutralizing capability of COV1-62; despite its lack of ACE2 blocking; underscores the importance of targeting various critical sites within the RBD for effective virus neutralization and highlights its potential in therapeutic settings.
- Isotyp:
- Human IgG1Lambda
- Aufreinigung:
- Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php