Anti-SARS-CoV-1; Spike (Clone COV1-57)-Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8258-250UG
1 mg
£812,00
12-8258-1MG
Über dieses Produkt
- SKU:
- 12-8258
- translate.label.attr.clone:
- COV1-57
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: COV1-57 is highly specific for the SARS-CoV-1 and SARS-CoV-2 prefusion spike protein (S2) distributed on the viral surface. Antigen Distribution: Anti-SARS-CoV-1 recognizes antigens on infected cells; including respiratory epithelial cells. Background: SARS-CoV-1; also known as the Severe Acute Respiratory Syndrome coronavirus; is a zoonotic virus that is believed to have originated from an animal reservoir; possibly horseshoe bats; and transmitted to humans1. This virus primarily affects the respiratory system and can cause symptoms such as muscle pain; headache; fever; cough; dyspnea; and pneumonia1;2. It was the first severe and readily transmissible new disease to emerge in the 21st century; with the capacity to spread globally via international air travel. The COV1-57 monoclonal antibody targets the prefusion spike protein of both SARS-CoV-1 and SARS-CoV-2; making it a cross-reactive antibody. Although it does not block the ACE2 receptor; COV1-57 functions as a neutralizing antibody; which means it can inhibit the virus's ability to infect host cells. The neutralizing activity of COV1-57 suggests that it can prevent the spike protein from undergoing the necessary conformational changes required for membrane fusion. The specific epitope targeted by COV1-57 remains unknown; which warrants further research to determine the precise binding site and mechanism of neutralization. This antibody could be valuable in therapeutic applications; especially in combination with other antibodies that target different epitopes.
- Isotyp:
- Human IgG1k
- Aufreinigung:
- Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php