Anti-Rift Valley Fever Virus; Glycoprotein (Gn) (Clone RVFV-436)-Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8248-250UG
1 mg
£812,00
12-8248-1MG
Über dieses Produkt
- SKU:
- 12-8248
- translate.label.attr.clone:
- RVFV-436
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Clone RVFV-436 binds the Gn glycoprotein of Rift Valley Fever Virus (RVFV). Antigen Distribution: RVFV is primarily found in hepatic cells; endothelial cells; and mononuclear phagocytes in the human body. This distribution reflects the virus's tendency to cause hepatitis; hemorrhagic fever; and encephalitis during infection. Background: RVFV is a mosquito-borne phlebovirus primarily found in sub-Saharan Africa; especially in eastern and southern Africa. It infects both humans and ungulates (such as cows; goats; and sheep). RVFV causes a wide range of health effects; from mild illness to severe conditions like hemorrhagic disease; encephalitis; hepatitis; kidney injury; and retinitis. The virus can lead to spontaneous abortions in animals. RVFV outbreaks often occur during years of unusually heavy rainfall and flooding; as mosquitoes hatch more eggs; increasing transmission potential1;2. RVFV-426 is a notable monoclonal antibody (mAb) that targets the Gn protein of the virus. This antibody exhibited significant neutralizing activity; with an IC50 value of 4.6 ng/mL for both the ZH501 and SA51 wild-type strains and 2.5 ng/mL for the MP-12 vaccine strain. The research underscores the potential of these mAbs in both prophylactic and therapeutic settings; offering a promising avenue for combating RVFV infections. The findings suggest that RVFV-436; along with other mAbs; could be further developed for use in humans to prevent or treat RVFV; which poses a significant threat to both human and animal health3.
- Isotyp:
- Human IgG1
- Aufreinigung:
- Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php