Anti-Rift Valley Fever Virus; Glycoprotein (Gc) (Clone RVFV-250)-Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8245-250UG
1 mg
£812,00
12-8245-1MG
Über dieses Produkt
- SKU:
- 12-8245
- translate.label.attr.clone:
- RVFV-250
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Clone RVFV-250 binds to a region of domain II (DII) adjacent to the fusion loop of the Gc glycoprotein of Rift Valley Fever Virus (RVFV). Antigen Distribution: RVFV is primarily found in hepatic cells; endothelial cells; and mononuclear phagocytes in the human body. This distribution reflects the virus's tendency to cause hepatitis; hemorrhagic fever; and encephalitis during infection. Background: RVFV is a mosquito-borne phlebovirus primarily found in sub-Saharan Africa; especially in eastern and southern Africa. It infects both humans and ungulates (such as cows; goats; and sheep). RVFV causes a wide range of health effects; from mild illness to severe conditions like hemorrhagic disease; encephalitis; hepatitis; kidney injury; and retinitis. The virus can lead to spontaneous abortions in animals. RVFV outbreaks often occur during years of unusually heavy rainfall and flooding; as mosquitoes hatch more eggs; increasing transmission potential1;2. RVFV-250 targets the Gc protein of RVFV. It has an IC50 value of 51 ng/mL for the MP-12 vaccine strain; indicating moderate neutralizing activity. However; it shows reduced neutralization potency against wild-type strains and SA51; with IC50 values of 120 ng/mL. RVFV-250 binds to specific regions on the Gc protein; contributing to its ability to neutralize the virus3.
- Isotyp:
- Human IgG1Lambda
- Aufreinigung:
- Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php