Anti-Marburg Virus; Glycoprotein (GP1) (Clone MARV-72)-Purified No Carrier Protein
Produktgrößen
250 µg
£583,00
12-8240-250UG
1 mg
£812,00
12-8240-1MG
Über dieses Produkt
- SKU:
- 12-8240
- Anwendung:
- Electron Microscopy
- translate.label.attr.clone:
- MARV-72
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: Clone MARV-72 is a human IgG monoclonal antibody that specifically targets the top portion from the head domain of glycoprotein 1 (GP1) of the Marburg Virus (MARV). Antigen Distribution: MARV initially infects monocytes; macrophages; and dendritic cells; which serve as the initial targets of infection and contribute to the spread of the virus throughout the body. Background: MARV is a highly pathogenic virus that belongs to the Filoviridae family; along with Ebola virus1. It can cause severe hemorrhagic fever in humans; with mortality rates as high as 90%2. MARV is transmitted to humans through contact with infected animals; such as fruit bats or monkeys; or direct contact with the bodily fluids of infected individuals3. There are currently no approved vaccines or specific treatments for MARV infection. Research has focused on understanding the virus's replication; immune evasion mechanisms; and developing potential vaccines and therapeutics. Animal models; such as nonhuman primates and guinea pigs; have been used to study the virus and evaluate potential interventions.? Studies on MARV's envelope GP have shown that the virus can evade antibody-mediated immune pressure through mutations in the furin-cleavage site and deletion of the mucin-like region; demonstrating the GP's structural flexibility and variability4. These findings contribute to our understanding of MARV's life cycle; immune evasion mechanisms; and potential therapeutic approaches. Clone MARV-72 (also known as MR72) is recognized for its wide-ranging reactivity against filoviruses; such as Ebola and Marburg viruses. It is noteworthy for being one of the rare antibodies capable of attaching to GPs of both types of viruses; making it highly sought after for therapeutic applications. MARV-72 has demonstrated its efficacy in neutralizing these viruses and offering protection in non-human primate models5.
- Isotyp:
- Human IgG1
- Aufreinigung:
- Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php