Anti-Chikungunya E2 Protein
Produktgrößen
50 µg
£705,00
12-8139-50UG
Über dieses Produkt
- SKU:
- 12-8139
- Zusätzliche Namen:
- CHIKV; Chikungunya virus; VLPs; Chikungunya virus-like particles
- translate.label.attr.clone:
- CHK152
- Klonalität:
- Monoclonal
- Weitere Details:
- Endotoxin Level : <1.0 EU/µg as determined by the LAL method Specificity : Clone CHK152 binds to and shows mechanisms of neutralizing of the Chikungunya E2 protein. Antigen Distribution : The E2 Envelope protein is expressed on the surface of the Chikungunya Virus. Background : Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics globally and has been declared a notable disease by the CDC . Symptoms include high fever; myalgia; rash; and severe polyarthritis which can persist for long after acute infection. CHIKV is an enveloped virus with an 11.8-kb single-stranded; positive-sense RNA genome with two open reading frames. There are three main genotypes; having 95.2 to 99.8% amino acid identity: Asian; West African; and East/Central/South African (ECSA). The mature CHIKV virion is comprised of a nucleocapsid protein C and two glycoproteins; E1 and E2. E1 participates in virus fusion. E2 functions in attachment to cells. E1 and E2 form 80 trimeric spikes on the virus surface . Co-circulation of CHIKV with other arboviruses; such as dengue; Zika; Mayaro; and yellow fever; occurs in many countries; posing significant difficulties for diagnosis. Monoclonal antibodies (MAb) can be used both for diagnosis and as a therapeutic agent. CHIKV can be rapidly detected by an immunochromatographic assay using MAbs against the CHIKV envelope protein. Additionally; MAb CHK-152 has been successfully used as a therapeutic agent in mouse and macaque. CHK-152 activity is directed against the A domain of CHIKV E2 and likely neutralizes infectivity by inhibiting fusion. MAb CHK-152 protects immunocompromised mice and macaque against CHIKV-induced mortality and disease; inhibiting all three CHIKV genotypes. Viral loads are markedly reduced in serum; spleen; liver; muscle; and brain relative to controls and joint tissue appears normal. Combination MAb therapy (CHK-102+CHK-152 or CHK-166+CHK-152); avoids the emergence of viral resistance (dominant single-mutation escape) in both mouse and macaque models 9 and the treatment window is extended. When humanized; hu-CHK-152 neutralizing activity and affinity for pE2-E1 are similar to mouse CHK-152.
- Host:
- Mouse
- Immunogen:
- Chikungunya E2 protein
- Isotyp:
- Mouse IgG2a
- Aufreinigung:
- >=95% monomer by analytical SEC>95% by SDS Page
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at -80[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php