Anti-Dengue Virus (Clone: DENV-2D22)
Produktgrößen
100 µg
£649,00
12-8125-100UG
Über dieses Produkt
- SKU:
- 12-8125
- Zusätzliche Namen:
- DENV
- translate.label.attr.clone:
- DENV-2D22
- Klonalität:
- Monoclonal
- Weitere Details:
- Reactivity Species : Dengue-Virus Expression Host : HEK-293 Endotoxin Level 1.0 EU/mg as determined by the LAL method Specificity : DENV-2D22 activity is DENV-2 specific and directed against the E homodimer at the DIII€¯+€¯glycan loop with serotype specificity on one E protein and DII around the fusion loop on the other E protein. Antibody clone DENV-2D22 was identified as strongly neutralizing; capable of inhibiting infection of DENV-2; and able to bind intact DENV-2 but not DIII or recombinant E. DENV-2D22 also did not bind to E protein by immunoblot. DENV-2D22 is E protein specific based on an escape mutant of DIII at R323G and recognizes a complex quaternary epitope displayed on the intact virus formed by DIII and DII on two different monomers within a single dimer. When the entire DENV-2 DIII region was inserted into the backbone sequence of a DENV-4 molecular clone to create a recombinant virus; DENV-2D22 was capable of binding and neutralization. Only five contact residues differ between DENV-2 and -4 in DIII; and these are likely critical for binding and neutralization. DENV-2D22 had no detectable ability to enhance DENV infection at a typical concentration range in a Ab-dependent enhancement assay; was capable of binding and neutralizing chimeric yellow fever-dengue vaccine virus serotype 2; and blocked viral infection of viremic blood for Ae. aegypti.
- Host:
- Human
- Immunogen:
- Sequenced from human survivors of who had experienced a DENV infection during travel to an endemic region.
- Isotyp:
- Human IgG1
- Aufreinigung:
- >=95% monomer by analytical SEC
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Functional grade preclinical antibodies may be stored sterile as received at 2-8[o]C for up to one year. For longer term storage; aseptically aliquot in working volumes without diluting and store at >= -70[o]C. Avoid Repeated Freeze Thaw Cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Datenblatt des Herstellers:download_pdf.php