Anti-Human CD49D (Integrin alpha 4) (Natalizumab) Fc Muted
Produktgrößen
100 µg
£760,00
12-8046-100UG
Über dieses Produkt
- SKU:
- 12-8046
- Zusätzliche Namen:
- CD49D; alpha 4 subunit of VLA-4 receptor; ITGA4; Integrin alpha-IV
- translate.label.attr.clone:
- Hu114
- Klonalität:
- Monoclonal
- Weitere Details:
- Expression Host : HEK-293 Pathogen Testing : To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens; all of this recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Natalizumab. Natalizumab binds to the alpha 4 subunit of alpha4beta1 and alpha4beta7 integrins. This product is for research use only. Natalizumab is characterized as a disease-modifying therapy for multiple sclerosis (a disease of the central nervous system (CNS)); and inflammatory bowel disease. It works by inhibiting the migration of leukocytes to inflammation sites. The VCAM-1 and alpha4beta1-integrin interaction is necessary for leukocyte adhesion; firm attachment; and transmigration across the blood-brain barrier into the CNS. Natalizumab; a recombinant; humanized antibody; binds to alpha4beta1 -integrin and blocks its interaction with VCAM-1. Hence; leukocyte migration into brain tissue is inhibited; thereby reducing inflammation and preventing the formation of multiple sclerosis lesions.1 Inflammation in the gut pertaining to inflammatory bowel disease can be controlled in a similar fashion. Blocking alpha4beta7-integrin with a humanized; monoclonal antibody; specific to the alpha4beta7 heterodimer inhibits the migration of leukocytes into the inflamed intestinal tissue; thus; reducing inflammation in the gut.2 This cost-effective; research-grade Anti-Human CD49D (Natalizumab) utilizes the same variable regions from the therapeutic antibody Natalizumab making it ideal for research projects.
- Host:
- Human
- Immunogen:
- RAMOS cell line injected into mice.
- Isotyp:
- Human IgG1k
- Aufreinigung:
- >=95% monomer by analytical SEC
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Functional grade biosimilar antibodies may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at -80[o]C. Avoid Repeated Freeze Thaw Cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php