Anti-Human HER-2 (Trastuzumab)
Produktgrößen
50 µg
£540,00
12-8001-50UG
100µg
£760,00
12-8001-100UG
Über dieses Produkt
- SKU:
- 12-8001
- Zusätzliche Namen:
- ErbB-2; NEU; NGL; HER2; TKR1; CD340; MLN 19; HER-2/neu
- translate.label.attr.clone:
- 4D5-8
- Klonalität:
- Monoclonal
- Weitere Details:
- Expression Host : HEK-293 Pathogen Testing : To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens; all of recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Trastuzumab. Clone 4D5-8 recognizes human erbB-2. This product is for research use only. Trastuzumab is a monoclonal antibody targeting HER2; a 185 kDa transmembrane glycoprotein that contains an extracellular domain and intracellular tyrosine kinase activity. When it is functioning normally; the HER2 pathway supports cell growth and division. On the other hand; the over expression of HER2 propels cell growth beyond its typical range. This overexpression is associated with some cancers; namely breast and stomach; in which the HER2 protein can be expressed up to 100 times more than in typical cells. Trastuzumab induces an immune-mediated response that triggers the internalization and downregulation of HER2 making it an excellent target for immunotherapy. Several clinical studies are under way which show that anti-HER-2/neu antibodies inhibit the growth and proliferation of these tumor cells In vitro as well as In vivo.
- Host:
- Human
- Immunogen:
- Human epidermoid carcinoma cells (A431) over-expressing EGFR.
- Isotyp:
- Human IgG1k
- Aufreinigung:
- >=95% monomer by analytical SEC
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Functional grade biosimilar antibodies may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at -80[o]C. Avoid Repeated Freeze Thaw Cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php