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Antikörper

Phospho-NFKB p65 (Ser468) (Clone: B9) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4344-20UL
200 µl
£1021,00
12-4344-200UL
Über dieses Produkt
SKU:
12-4344
Zusätzliche Namen:
Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; RELA; NFKB3
translate.label.attr.clone:
NFKBp65S468-B9
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
The nuclear factor kB (NFkB)/Rel family of transcription factors play a pivotal role in inflammatory and immune responses (1;2). NF-kappa-B is present in almost all cell types and is involved in many biological processes including immunity; inflammation; cell growth and differentiation; apoptosis; and tumorigenesis. NFkB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65; RELB; NFkB1/p105; NFkB1/p50; REL and NFkB2/p52. The dimers bind at kB sites in the target gene DNA. Individual dimers have distinct preferences for different kB sites and can act as either transcriptional activators or repressors. NFkB Ser536 phosphorylation stimulates Lys310 acetylation and interaction of phospho NFkB with CBP. Acetylated/phospho NFkB induces enhanced transcriptional activity.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser536 of human phospho-NFKB p65
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of A431cells secondary antibody only negative control (light blue) or untreated (red) or treated with staurosporine (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-NFkB p65 (Ser468) antibody NFkBp65S468-B9 at 0.01µg/mL.
Fig 2 : Peptide blocking flow cytometric analysis of A431cells secondary antibody only negative control (light blue) or untreated (red) or treated with staurosporine (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-NFkB p65 (Ser468) antibody NFkBp65S468-B9 at 0.01µg/mL.