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Antikörper

Phospho-Lyn (Tyr507) (Clone: 5B6) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4324-20UL
200 µl
£1021,00
12-4324-200UL
Über dieses Produkt
SKU:
12-4324
Zusätzliche Namen:
Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; JTK8
translate.label.attr.clone:
LynY507-5B6
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
Lyn; along with Btk; supports the abnormal growth and survival of neoplastic mast cells. Phosphorylated Lyn has been identified in these cancerous cells; along with phosphorylated Btk; Hck; and Stat5. Dasatinib; a chemotherapy drug used to treat leukemia; is a tyrosine kinase inihibitor that binds directly to Lyn in neoplastic cells. Lyn and Btk have also been shown to be involved in IgE receptor-dependent activation. Increased Lyn activity; detected by higher amounts of phospho Lyn; has been demonstrated in breast cancer cell lines. This is likely mediated through effects of upstream regulators of Lyn; rather than mutations in Lyn itself.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr507 of human phospho Lyn
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of Jurkat cells secondary antibody only negative control (light blue) or untreated (red) or treated with IFNa + IL-4 + pervanadate (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-Lyn (Tyr507) antibody LynY507-5B6 at 0.01µg/mL.
Fig-3: Flow cytometric analysis of C2C12 cells secondary antibody only negative control (blue) or treated with imatinib (red) or with pervanadate (green) using Phospho-Lyn (Tyr507) antibody LynY507-5B6 at 0.01µg/mL.
Fig-4: Western blot analysis of Hela cell extract; untreated or treated with H2O2 using Phospho-LYN(TYR507) antibody LYNY507-5B6 at 0.01 µg/mL.
Fig-4: Western blot analysis of Hela cell extract; untreated or treated with H2O2 using Phospho-LYN(TYR507) antibody LYNY507-5B6 at 0.01 µg/mL.
Fig-5: Western blot analysis of HeLa cell extract; untreated or treated with H2O2 using 0.01 µg/mL Phospho-Lyn (Tyr507) antibody LynY507-5B6 or Company A antibody at 1 µg/mL (manufacturer's recommended concentration) developed using the same exposure.