Phospho-Jak1 (Tyr1022/1023) (Clone: F11) rabbit mAb FITC Conjugate
Produktgrößen
10 Tests
£532,00
12-4322-10TESTS
100 Tests
£792,00
12-4322-100TESTS
Über dieses Produkt
- SKU:
- 12-4322
- Zusätzliche Namen:
- Tyrosine-protein kinase JAK1; Janus kinase 1
- translate.label.attr.clone:
- Jak1Y10221023-F11
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- Jak1 plays an essential role in the IFN- alpha and IFN-g response pathways and is tyrosine-phosphorylated upon cellular exposure to these signals. Jak1 oral inhibitors have been used to benefit patients with advanced myelofibrosis; where Jak1 was initially shown to be constitutively active in the peripheral blood cells of these patients. Targeted; small-molecule Jak inhibitors have also been used for treatment of rheumatoid arthritis. In cases of advanced melanoma; acquired resistance to PD-1 blockade drugs is associated with loss-of-functions of mutations in Jak1/2 genes. These mutations block interferon gamma signaling and prevent programmed death ligand 1 (PD-L1) expression in tumor cells.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg