Skip to content

Warenkorb

Der Warenkorb ist leer.

Gesamt (exkl. MwSt.) £0,00
Warenkorb überprüfen & bezahlen
Antikörper

Phospho-Jak1 (Tyr1022/1023) (Clone: F11) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4320-20UL
200 µl
£1021,00
12-4320-200UL
Über dieses Produkt
SKU:
12-4320
Zusätzliche Namen:
Tyrosine-protein kinase JAK1; Janus kinase 1
translate.label.attr.clone:
Jak1Y10221023-F11
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
Jak1 plays an essential role in the IFN- alpha and IFN-g response pathways and is tyrosine-phosphorylated upon cellular exposure to these signals. Jak1 oral inhibitors have been used to benefit patients with advanced myelofibrosis; where Jak1 was initially shown to be constitutively active in the peripheral blood cells of these patients. Targeted; small-molecule Jak inhibitors have also been used for treatment of rheumatoid arthritis. In cases of advanced melanoma; acquired resistance to PD-1 blockade drugs is associated with loss-of-functions of mutations in Jak1/2 genes. These mutations block interferon gamma signaling and prevent programmed death ligand 1 (PD-L1) expression in tumor cells.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Flow cytometric analysis of C2C12 cells secondary antibody only negative control (blue) or treated with imatinib (red) or with pervanadate (green) using Phospho-Jak1 (Tyr1022/1023) antibody Jak1Y10221023-F11 at 0.01µg/mL.
Fig-3: Peptide blocking flow cytometric analysis of Jurkat cells secondary antibody only negative control (light blue) or untreated (red) or treated with IFNa + IL-4 + pervandadate (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-Jak1 (Tyr1022/1023) antibody Jak1Y10221023-F11 at 0.001µg/mL.
Fig-3: Peptide blocking flow cytometric analysis of Jurkat cells secondary antibody only negative control (light blue) or untreated (red) or treated with IFNa + IL-4 + pervandadate (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-Jak1 (Tyr1022/1023) antibody Jak1Y10221023-F11 at 0.001µg/mL.