Phospho-SAPK/JNK (Thr183/Tyr185) (Clone: A11) rabbit mAb PE conjugate
Produktgrößen
10 Tests
£532,00
12-4286-10TESTS
100 Tests
£792,00
12-4286-100TESTS
Über dieses Produkt
- SKU:
- 12-4286
- Zusätzliche Namen:
- Mitogen-activated protein kinase 8; MAPK8; Stress-activated protein kinase 1c; SAPK1c; c-Jun N-terminal kinase 1; JNK1; PRKM8
- translate.label.attr.clone:
- SAPKT183Y185-A11
- Klonalität:
- Monoclonal
- Konjugat:
- PE
- Weitere Details:
- The SAPK/JNK pathway initiates apoptosis upon exposure to radiation; UV exposure; heat shock; oxidative stress; and other stressors. Upon exposure to environmental stress; the SAPK/JNK signaling pathway sequentially activates the proteins MEKK1; SEK1; SAPK; and c-Jun. Upstream activators of the SAPK/JNK cascade include ceramide; small GTP-binding proteins such as Rac1 and Cdc42Hs; Ask1; and caspases. MKK7 is also a major and direct SAPK/JNK activator in the TNF alpha or environmental stress signaling pathways; where its kinase activity directly phosphorylates SAPK/JNK. This relationship between MKK7 and SAPK appears to be evolutionarily conserved; as it is preserved in their Drosophila homologues; Hep and DJNK; respectively.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr183/Tyr185 of human phospho SAPK/JNK
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg