Phospho-Shp1 (Tyr536) (Clone: 2A7) rabbit mAb
Produktgrößen
20 µl
£631,00
12-4281-20UL
200 µl
£1021,00
12-4281-200UL
Über dieses Produkt
- SKU:
- 12-4281
- Zusätzliche Namen:
- Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; SH-PTP1; PTPN6; HCP; PTP1C
- translate.label.attr.clone:
- Shp1Y536-2A7
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Src homology-2 domain containing phosphatase-1 (Shp1) typically functions as a negative regulator for signal transduction; interacting with Zap70; CD5; CD3e; and IL-2R in T cells. Shp1 suppresses cellular signaling by dephosphorylating target proteins. Shp1 is expressed predominantly in hematopoietic cells; where it can plays a role in malignant transformation into cancer cells. Methylation of the Shp1 promoter has been shown to silence Shp1 expression and promote the development of cancer. Shp1 negatively regulates PDGF and insulin tyrosine receptor pathways; and negatively regulates Lck in the TCR signaling pathway to limit TCR responsiveness. Shp1 activity is prevented by TAOK3 in T cells to allow for T cell activation and differentiation.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr536 of human phospho Shp1
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg