Phospho-PLK1 (Thr210) (Clone: C2) rabbit mAb
Produktgrößen
20 µl
£631,00
12-4277-20UL
200 µl
£1021,00
12-4277-200UL
Über dieses Produkt
- SKU:
- 12-4277
- Zusätzliche Namen:
- Serine/threonine-protein kinase PLK1; Polo-like kinase 1; Serine/threonine-protein kinase 13; STPK13
- translate.label.attr.clone:
- PLK1T210-C2
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- PLK1 is activated by phosphorylation of Thr210 in its activation loop. When dephosphorylated; PLK1 auto-inhibition occurs when the Polo-box domain (PDB) binds (and thus inhibits) the kinase domain. PLK1 phosphorylation is directly linked to the cell cycle; as phosphorylation occurs during mitosis but not during interphase. PLK1 is required for successful progression through the mitotic phase. Aurora A phosphorylates PLK1; with the G2-induced Bora protein directly interacting with PLK1 to relieve auto-inhibition. Small-molecule PLK1 inhibitors have played an important role in elucidating PLK1's activities in the cell and have demonstrated the potential of PLK1 as an anti-cancer target. PLK1 inhibition is an efficient cell killer.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
