Phospho-BLNK (Tyr84) (Clone: H4) rabbit mAb SureLight488 conjugate
Produktgrößen
10 Tests
£532,00
12-4239-10TESTS
100 Tests
£792,00
12-4239-100TESTS
Über dieses Produkt
- SKU:
- 12-4239
- Zusätzliche Namen:
- B-cell linker protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP65; B-cell adapter containing a SH2 domain protein; BASH
- translate.label.attr.clone:
- BLNKY84-H4
- Klonalität:
- Monoclonal
- Konjugat:
- SureLight 488
- Weitere Details:
- BLNK protein; known as SLP-65 play an important role as adaptor protein in B-lineage cells. BLNK associates with proteins in the cytoplasmic side of plasma membrane through its N-terminal leucine zipper motif. Upon BLNK activation on its tyrosine; BLNK binds to Btk; Vav; Brb2; Syk; and HPK1. Through this associations; BLNK mediates Ca2+ mobilization; for ERK1/2; JNK and p38 MAP kinase activation. After phosphorylation; BLNK binds Btk and PLCg2 through their SH2 domains and mediates PLCg2 activation by Btk. BLNK also binds other signaling molecules such as Vav; Grb2; Syk; and HPK1. BLNK plays aa important role in BCR-dependent progression of B cell development; BCR-mediated B cell survival; activation; proliferation; and T-independent immune responses.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr84 of human phospho BLNK
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg