Phospho-RelB (Ser552) (Clone: A7) rabbit mAb PE conjugate
Produktgrößen
10 Tests
£532,00
12-4209-10TESTS
100 Tests
£792,00
12-4209-100TESTS
Über dieses Produkt
- SKU:
- 12-4209
- Zusätzliche Namen:
- I-Rel
- translate.label.attr.clone:
- RelBS552-A7
- Klonalität:
- Monoclonal
- Konjugat:
- PE
- Weitere Details:
- RelB contains the Rel homology Domain (RHD) shared by all members of the NF-kB family (1). It is best known for its roles in lymphoid development; DC biology; and noncanonical signaling (2). RelB is a major contributor to chromatin biology; frequently functioning as a dual transcription factor that silences sets of genes by generating silent facultative heterochromatin and activates euchromatin of others (3). RelB is required to repress immediate-response proinflammatory genes during endotoxin tolerance (4). The N-terminal leucine zipper motif of RelB; a motif unique among the NF-kB family; may associate with more diverse DNA sequences than other NF-kB members (5). RelB binds to DNA but only after forming a heterodimer with NF-kB p50 or p52 (6). Like all NF-kB members; RelB contains an approximately 300-residue region known as the RHD. This region supports many of the NF-kB essential functions; such as DNA binding; dimerization; and nuclear localization (7). RelB; unlike other NF-kB members; has an N-terminal leucine zipper motif (1); a domain that can typically interact with many proteins (8). p100; the C-terminus of NF-kB2 acts as a RelB inhibitor (9); where it sequesters RelB in the cytosol to repress its activity. RelB is phosphorylated rapidly at threonine 84 and serine 552; causing cleavage at the N-terminus and its degradation by the proteasome (10). These phosphorylations are mediated by glycogen synthase kinase-3B; specific inhibition of which blocks phospho RelB phosphorylation and degradation (11). This degradation does not occur when phospho RelB is phosphorylated at serine 368; allowing its association with and stabilization by p100 (12).
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser552 of human phospho RelB
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg