Phospho-MAPKAPK2 (Thr334) (Clone: H2) rabbit mAb APC conjugate
Produktgrößen
10 Tests
£532,00
12-4194-10TESTS
100 Tests
£792,00
12-4194-100TESTS
Über dieses Produkt
- SKU:
- 12-4194
- Zusätzliche Namen:
- MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2; MK2
- translate.label.attr.clone:
- MAPKAPK2T334-H2
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (phospho MAPKAPK-2 or phospho MK2) is phosphorylated and activated by the p38 MAPK and it is known to transduce a range of extracellular signals that result in inflammatory response; cell division and differentiation; apoptosis; and cell motility (1;2). p38 MAPK through MK2 regulates biosynthesis of tumor necrosis factor alpha (TNF alpha) and other cytokines (3). In addition; MK2 is involved with phosphorylating of heat shock protein 27 (Hsp27)(4); pointing to prominent role for MK2 in cancer promotion. MK2 is also activated after DNA damage (5;6); resulting in cell cycle arrest such that cells have the capacity to repair their DNA and continue to proliferate. p38 MAPK phosphorylate MK2 in response to stress stimuli at Thr222; Ser272 and Thr334 (7). Thr334 phosphorylation serves as a switch for phospho MAPKAPK-2 nuclear import and export. In resting cells; p38 MAPK and MK2 form a complex in the nucleus (7). Cellular stress causes the phosphorylation of p38 MAPK by upstream kinases; such as MAPK kinase 3. The activated p38 MAPK then phosphorylates MK2 at Thr222; Ser272; and/or Thr334. When activated at Thr334; both p38 MAPK and MK2 translocate to the cytoplasm. Phosphorylation at Thr222 within the activation loop is crucial for MK2-dependent activation of several target substrates; including enzymes; proteins that regulate cytoskeleton motility; mRNA-binding proteins; and regulators of the cell cycle and apoptosis (8).
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr334 of human phospho MAPKAPK-2.
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg