Phospho-PTEN (Ser380/Thr382/383) (Clone: E4) rabbit mAb FITC conjugate
Produktgrößen
10 Tests
£532,00
12-4177-10TESTS
100 Tests
£792,00
12-4177-100TESTS
Über dieses Produkt
- SKU:
- 12-4177
- Zusätzliche Namen:
- Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase; Mutated in multiple advanced cancers 1; MMAC1; Phosphatase and tensin homolog; TEP1
- translate.label.attr.clone:
- PTENS380T382383-E4
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- PTEN has been identified as a tumor suppressor gene and has been found to be mutated in a significant number of human cancers; including prostate; brain; and breast cancer. PTEN shares sequence homology with the protein-tyrosine phosphatase (PTPase) family of proteins and negatively regulates the PI3K/Akt pathway. PTEN de-phosphorylates target proteins; and recombinant PTEN has been shown to have phosphoinositide 3-phosphhatase and inositol phosphate 3-phosphatase activity. Studies of primary tumor cells show a loss of PTEN expression after metastasis to the brain; via astrocyte-derived microRNAs. A cluster of phosphorylation sites (S380; T382; T383; and S385) in the C-terminal tail of PTEN drive a conformational change that reduces PTEN activity by inhibiting membrane interactions.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser380 and Thr382/383 of human phospho PTEN
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg