Phospho-NDRG1 (Thr346) (Clone: F5) rabbit mAb APC conjugate
Produktgrößen
10 Tests
£532,00
12-4170-10TESTS
100 Tests
£792,00
12-4170-100TESTS
Über dieses Produkt
- SKU:
- 12-4170
- Zusätzliche Namen:
- Differentiation-related gene 1 protein; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42
- translate.label.attr.clone:
- NDRG1T346-F5
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- N-Myc down-regulated gene 1 (NDRG1) has been reported to be a direct transcriptional target of p53. NDRG1 appears to play a necessary; but not sufficient; role in apoptosis; though its exact mechanism of action remains unknown. NDRG1 expression is elevated in non-small cell lung cancer cells; promoting cancer growth and reducing cytotoxicity to certain anti-cancer drugs. NDRG1 is also elevated in solid tumors and is recognized as a negative prognostic indicator in breast cancer. Elevated NDRG1 expression is correlated with disease recurrence and metastasis in breast cancer. NDRG1 is phosphorylated by Sgk1; which itself is activated by mTORC2. Phosphorylation of NDRG1 at Thr346 promotes cellular differentiation in adipocytes.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phosphor-peptide corresponding to residues surrounding Thr346 of human phospho NDRG1
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg