Phospho-p38 MAPK (Thr180/Tyr182) (Clone: E3) rabbit mAb FITC conjugate
Produktgrößen
10 Tests
£532,00
12-4145-10TESTS
100 Tests
£792,00
12-4145-100TESTS
Über dieses Produkt
- SKU:
- 12-4145
- Zusätzliche Namen:
- CSAID-binding protein; CSBP; CSPB1; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase MXI2; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase 14; MK14; MXI2; PRKM14; RK; SAPK2A; stress-activated protein kinase 2A
- translate.label.attr.clone:
- P38T180Y182-E3
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- P38 mitogen-activated protein kinase (MAPK) is a stress-activated serine/threonine protein kinase and belongs to the MAP kinase superfamily. Various stress stimuli such as ultraviolet light; irradiation; heat shock; proinflammatory cytokines; mitogens; and high osmotic stress can activate p38 MAPK through phosphorylation of a TGY motif within the kinase activation loop (1). This event plays an improtant role in cell differentiation; apoptosis and autophagy. MKK3 and SEK activate p38 MAPK by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2; Mac and MEF2. p38 MAPK also has been shown to phosphorylate post-transcriptional regulating factors like TTP (2).
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr180/Tyr182 of human phospho p38 MAPK.
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg