Phospho-PDK1 (Ser241) (Clone: F7) rabbit mAb
Produktgrößen
20 µl
£631,00
12-4136-20UL
200 µl
£1021,00
12-4136-200UL
Über dieses Produkt
- SKU:
- 12-4136
- Zusätzliche Namen:
- 3-phosphoinositide-dependent protein kinase 1; PDPK1
- translate.label.attr.clone:
- PDK1S241-F7
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- PDK1 is a Ser/Thr kinase that is ubiquitously expressed throughout human tissues. PDK1 phosphorylates protein kinase B (PKB or Akt) at both Thr308 and Ser473 in vivo. PDK1 is active and phosphorylated in basal conditions; where it exists predominantly in the cytosol with a small fraction at the plasma membrane. This membrane association is likely mediated by PDK1 binding to phospholipids through its PH domain; which has been found to have strong affinity to specific phospholipids. PDK1 is a master regulator of at least 23 related protein kinases; and more than 50% of all human cancers show significant overstimulation of the PDK1 pathway. Most small-molecule inhibitors of PDK1 target the ATP binding site.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDK1
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
