Phospho-Stat1 (Tyr701) (Clone: 3E6) rabbit mAb FITC conjugate
Produktgrößen
10 Tests
£532,00
12-4108-10TESTS
100 Tests
£792,00
12-4108-100TESTS
Über dieses Produkt
- SKU:
- 12-4108
- Zusätzliche Namen:
- Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
- translate.label.attr.clone:
- Stat1Y701-3E6
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- Stat1 mediates the cellular response to IFN alpha; IFNB; and IFNg for the regulation of cell growth and the defense against viral and immune challenges. The Jak-Stat pathway plays a central role in the IFNg response; where Stat1 phosphorylation on Tyr701 causes homodimerization through its SH2 domain; translocation to the nucleus; and binding to gamma-activated sequence (GAS) elements. Early in the activation sequence; Stat1 is also phosphorylated at Ser727 through a mechanism involving PI3 kinase and Akt. Stat1 has been found to correlate with increased resistance to chemotherapeutic drugs. However; Stat1 activation of the immune system helps suppress tumor growth; and multiple melanomas and squamous-cell carcinomas have been known to downregulate Stat1 expression to evade immune surveillance.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr701 of human phospho Stat1
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg