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Antikörper

Phospho-MET (Tyr1234/1235) (Clone: 6F11) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4101-20UL
200 µl
£1021,00
12-4101-200UL
Über dieses Produkt
SKU:
12-4101
Zusätzliche Namen:
AUTS9; c-Met; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; MET; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; RCCP2; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
translate.label.attr.clone:
MetY12341235-6F11
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
c-Met; also called tyrosine-protein kinase MET or hepatocyte growth factor receptor (HGFR); has tyrosine kinase activity (1). MET is a single pass tyrosine kinase receptor essential for embryonic development; organogenesis and wound healing. Normally; MET is expressed only in stems cells and progenitor cells but excessive expression of MET/HGFR and its autocrine activation by co-expression of hepatocyte growth factor (HGF) ligand are implicated in oncogenesis (2;3). Aberrantly activated MET leads to tumor growth; angiogenesis; and cancer metastasis and is correlated with poor prognosis. Abnormal activation of MET is observed in various human malignancies; such as kidney; liver; stomach; breast; and brain. MET activation by HGF induces MET kinase catalytic activity and leads to phosphorylation at Tyr 1234 and Tyr 1235.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Flow cytometric analysis of Ramos cells secondary antibody only negative control (blue) untreated (red) treated with FBS + pervanadate (green) treated plus blocked by non-phospho peptide (violet) or treated plus blocked by phospho-peptide (brown) using 0.01 µg/mL Phospho-MET(Y1234/1235) antibody METY12341235-6F11 0.01 µg/mL.
Fig-3: Flow cytometric analysis of NIH3T3 cells secondary antibody only negative control (blue) or 0.1 µg/mL of isotype control (orange) or treated with imatinib (red) or with pervanadate (green) using Phospho-MET(Y1234/1235) antibody METY12341235-6F11 at 0.1 µg/mL.
Fig-4: Flow cytometric analysis of Ramos cells secondary only negative control (blue) or untreated (red) or treated with FBS + pervanadate (green) using Phospho-Met (Tyr1234/1235) antibody MetY12341235-6F11 at 0.01µg/mL or Company C antibody at 0.2µg/mL (manufacturer's recommended concentration).
Fig-4: Flow cytometric analysis of Ramos cells secondary only negative control (blue) or untreated (red) or treated with FBS + pervanadate (green) using Phospho-Met (Tyr1234/1235) antibody MetY12341235-6F11 at 0.01µg/mL or Company C antibody at 0.2µg/mL (manufacturer's recommended concentration).