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Antikörper

Phospho-PLCg1 (Tyr783) (Clone: C4) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4096-20UL
200 µl
£1021,00
12-4096-200UL
Über dieses Produkt
SKU:
12-4096
Zusätzliche Namen:
1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; Phospholipase C-gamma-1; PLC-gamma-1; PLC1
translate.label.attr.clone:
PLCG1Y783-C4
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositolphosphate to inositol triphosphate and diacylglycerol. In response to extracellular stimuli such as hormones; growth factors and neurotransmitters; PLC hydrolyzes phosphatidylinositol 4;5-bisphosphate (PIP2) to generate diacylglycerols (DAGs) and water-soluble phosphorylated derivatives; such as inositol 1;4;5-triphosphate (IP3). Within the PLC family; PLCg is the only member that contains SH2 and SH3 domains; necessary for phospho PLCg activation. Phospho PLCg; upon activation; can interact with receptor tyrosine kinases.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr783 of human phospho PLCg1.
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Peptide blockage flow cytometric analysis of Hela cells secondary antibody only negative control (blue) treated with imatinib (red) treated with pervanadate (green) treated with PV + blocked with non-phospho- peptide (violet) or treated with PV + blocked with phospho-peptide (brown) using Phospho-PLCg1 (Tyr783) antibody at 0.05 µg/mL PLCg1Y783-C4.
Fig-3: PLCg1Y783-C4 recognizes basal phosphorylation levels in mouse cells. Flow cytometric analysis of L929 cells secondary antibody only (blue) or 0.1 µg/mL of isotype control (Cat# 12-4086) (orange) or of Phospho-PLCg1 (Tyr783) antibody PLCg1Y783-C4 (green).
Fig-4: Flow cytometric analysis of HeLa cells secondary antibody only negative control (blue) or treated with imatinib (red) or with pervanadate (green) using Phospho-PLCg1 (Tyr783) antibody PLCg1Y783-C4 or Company C antibody at 0.1 µg/mL (manufacturer's recommended concentration).
Fig-4: Flow cytometric analysis of HeLa cells secondary antibody only negative control (blue) or treated with imatinib (red) or with pervanadate (green) using Phospho-PLCg1 (Tyr783) antibody PLCg1Y783-C4 or Company C antibody at 0.1 µg/mL (manufacturer's recommended concentration).