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Antikörper

Phospho-Histone H2A.X (Ser139) (Clone: 1B3) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4094-20UL
200 µl
£1021,00
12-4094-200UL
Über dieses Produkt
SKU:
12-4094
Zusätzliche Namen:
H2AFX; H2AX; ?H2AX; gamma-H2AX
translate.label.attr.clone:
HisH2AXS139-1B3
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
Histone H2AX is a variant of the nucleosome core histone H2A and is phosphorylated at Ser139 in response to DNA damage. Histone H2AX phosphorylation is considered a specific reporter of double-strand DNA breaks. The protein is also referred to as gH2AX when phosphorylated at Ser139. H2AX phosphorylation is especially strong in response to double-strand breaks formed during apoptosis. However; physiological phosphorylation of Histone H2AX occurs when double-strand DNA breaks are formed during meiosis and V(D)J recombination. A549 and DU145 cell lines have been found to have higher expression levels of phosphorylated Histone H2AX compared to Jurkat; MCF-7; or HL-60 cell lines.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of 293T cells secondary antibody only negative control (blue) or untreated (red) or treated with UV and PMA (green) or untreated and blocked with phospho-peptide (gray) or treated and blocked with phospho peptide (orange) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-Histone H2A.X (Ser139) antibody HisH2AXS139-1B3 at 0.1 µg/mL.
Fig-3: Western blot analysis of 293T cell extract untreated or treated with UV using 0.05 µg/mL Phospho-Histone H2A.X(Ser139) antibody HisH2AXS139-1B3.
Fig-4: Flow cytometric analysis of 3T3 cells secondary antibody only (blue) or untreated with 0.1 µg/mL of isotype control (orange) or untreated (red) or UV and PMA-treated (green) using phospho-Histone H2A.X (Ser139) antibody HisH2AXS139-1B3.
Fig-4: Flow cytometric analysis of 3T3 cells secondary antibody only (blue) or untreated with 0.1 µg/mL of isotype control (orange) or untreated (red) or UV and PMA-treated (green) using phospho-Histone H2A.X (Ser139) antibody HisH2AXS139-1B3.
Fig-5: Flow cytometric analysis of C2C12 cells secondary antibody only (blue) untreated (red) or UV and PMA-treated (green) using phospho-Histone H2A.X (Ser139) antibody HisH2AXS139-1B3 at 0.1 µg/mL.