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Antikörper

Phospho-MKK7 (Ser271/Thr275) (Clone: R4F9) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4088-20UL
200 µl
£1021,00
12-4088-200UL
Über dieses Produkt
SKU:
12-4088
Zusätzliche Namen:
Dual specificity mitogen-activated protein kinase kinase 7; MAP kinase kinase 7; MAPKK 7; JNK-activating kinase 2; MAPK/ERK kinase 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; SAPKK4; c-Jun N-terminal kinase kinase 2; JNK kinase 2; MAP2K7; JNKK2; MEK7; PRKMK7; SKK4
translate.label.attr.clone:
MKK7S271T275-R4F9
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
MKK7 is a dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is an essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4; is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1; MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation; but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that phospho MKK7 is important to trigger JNK activity; while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Phospho MKK7 has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway; including the release cytochrome c; leading to apoptosis.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser271/Thr275 of human phospho MKK7
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse, Rat
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Western blot analysis of THP1 cell extract untreated or treated with sorbitol using 0.1 µg/mL Phospho-MKK7 (Ser271/Thr275) antibody MKK7S271T275-R4F9.
Fig-3: Flow cytometric analysis of C2C12 cells secondary antibody only negative control (blue) or 1 µg/mL of isotype control (orange) or untreated (red) or treated with staurosporine (green) using Phospho-MKK7 (Ser271/Thr275) antibody MKK7S271T275-R4F9 at 1 µg/mL.
Fig-3: Flow cytometric analysis of C2C12 cells secondary antibody only negative control (blue) or 1 µg/mL of isotype control (orange) or untreated (red) or treated with staurosporine (green) using Phospho-MKK7 (Ser271/Thr275) antibody MKK7S271T275-R4F9 at 1 µg/mL.