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Phospho-Shp2 (Tyr580) (Clone: 4A2) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4076-20UL
200 µl
£1021,00
12-4076-200UL
Über dieses Produkt
SKU:
12-4076
Zusätzliche Namen:
Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; SH-PTP3; PTPN11; PTP2C; SHPTP2
translate.label.attr.clone:
Shp2Y580-4A2
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (Shp2; phospho Shp2); encoded by PTPN11 gene; is a non-receptor phosphotyrosine phosphatase which is ubiquitously expressed in mammalian cells and contain one protein tyrosine phosphatase (PTP) catalytic domain and two SH2 domains. The phosphatase active site is located in the C-terminal of Shp2. Shp2 is phosphorylated by several stimulants and cytokines at Tyr580 inducing Shp2 activation. Activated Shp2 recruits Grb2 and Tyr580 phosphorylation of phospho Shp2 functions as the main binding site of Grb2; thereby activating downstream Ras in response to growth factors. In turn Grb2 controls FGFR2 phosphorylation by inhibiting receptor kinase and Shp2 phosphatase activity. Shp2 also promotes both ERK1/2 and PI3K/AKT signaling. High levels of Shp2 has been found in several cancer types including breast cancer and melanoma.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of THP1 cells secondary antibody only negative control (light blue) or untreated (red) or treated with IFNa + IL-4 + pervanadate (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) using Phospho-Shp2 (Tyr580) antibody Shp2Y580-4A2 at 0.1µg/mL.
Fig-3: Flow cytometric analysis of NIH3T3 cells secondary antibody only negative control (blue) or 0.1 µg/mL of isotype control (orange) or untreated (red) or treated with IFNa IL-4 and pervanadate (green) using Phospho-Shp2 (Tyr580) antibody Shp2Y580-4A2 at 0.1 µg/mL.
Fig-3: Flow cytometric analysis of NIH3T3 cells secondary antibody only negative control (blue) or 0.1 µg/mL of isotype control (orange) or untreated (red) or treated with IFNa IL-4 and pervanadate (green) using Phospho-Shp2 (Tyr580) antibody Shp2Y580-4A2 at 0.1 µg/mL.