Phospho-EGFR (Tyr1068) (Clone: E5) rabbit mAb APC conjugate
Produktgrößen
10 Tests
£532,00
12-4071-10TESTS
100 Tests
£792,00
12-4071-100TESTS
Über dieses Produkt
- SKU:
- 12-4071
- Zusätzliche Namen:
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian); ERBB; ERBB1; HER1; mE
- translate.label.attr.clone:
- EGFRY1068-E5
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands (1). EGFR (rbB-1) is closely related to other members of the ErbB family of receptors: HER2/neu(ErbB-2); HER3 (ErbB-3) and HER4 (ErbB-4). In many cancer types; mutations affecting EGFR expression or activity could result in cancer (2). Overexpression of EGFR is associated with the development of a wide variety of tumors. Interruption of EGFR signaling; either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity; can prevent the growth of EGFR-expressing tumors and improve the patient's condition. EGFR is activated by the binding of its ligands including EGF and dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. Activation of EGFR leads to autophosphorylation of tyrosine (Tyr) residues; Tyr992; Tyr1045; Y1068; Tyr1148; and Tyr1173 in the C-terminal domain.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR.
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg