Phospho-Zap70 (Tyr319)/Syk (Tyr352) (Clone: A3) rabbit mAb
Produktgrößen
20 µl
£631,00
12-4065-20UL
200 µl
£1021,00
12-4065-200UL
Über dieses Produkt
- SKU:
- 12-4065
- Zusätzliche Namen:
- Tyrosine-protein kinase ZAP-70 ; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase; SRK; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk
- translate.label.attr.clone:
- Zap70Y319-A3
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- ZAP70 (Tyrosine-protein kinase ZAP-70; phospho Zap70) is a protein tyrosine kinase (PTK) that associates with the z subunit of the T cell antigen receptor (TCR) and undergoes tyrosine phosphorylation following TCR stimulation. Following TCR engagement; Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. ZAP70 contains two SH2-like domains with the PTK domain located at the C-terminus. It appears that both phospho Zap70 and Syk are recruited to the phosphorylated CD3 and z subunits after TCR stimulation. Phosphorylation of Tyr319 is required for the assembly of a phospho Zap70-containing signaling complex that leads to the activation of the PLC-gamma1-dependent and Ras-dependent signaling cascades in antigen-stimulated T cells. The orthologous Tyr352 residue in Syk is also involved in the association with PLC-gamma1.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
