Phospho-ATF2 (Thr71) (Clone: G3) rabbit mAb APC conjugate
Produktgrößen
10 Tests
£532,00
12-4053-10TESTS
100 Tests
£792,00
12-4053-100TESTS
Über dieses Produkt
- SKU:
- 12-4053
- Zusätzliche Namen:
- Cyclic AMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; HB16; CREB2; CREBP1
- translate.label.attr.clone:
- ATF2T71-G3
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- Activating transcription factor 2 (ATF2); known as cyclic AMP (cAMP) response element (CRE) binding protein 2 (CREB2) and CRE-BP1 is a member of the activating protein-1 (AP1) transcription factor family. Through homo-dimerization or hetero-dimerization with other AP1 family members; such as the CREB; Fos; Maf; or Jun family transcription factor; it regulates the expression of many genes. ATF2 is an important mediator of mammalian cell responses to various stimuli; including stress. As a transcription factor; ATF2 acts as transducing extracellular signals to the nucleus to facilitate transcriptional responses to stimuli. ATF2 is stimulated by growth factors; ultraviolet (UV) radiation; and cytokines. Stress-activated protein kinases (SAPKs)(e.g. p38 MAP Kinase) induce transcriptional activation of ATF2. ATF2 is phosphorylated at amino acids threonine-69 and threonine-71 (T69; T71). Phosphorylation at these threonine residues is essential for maximal transcriptional activity downstream of insulin/epidermal growth factor stimulation and is dependent on cooperation between c-Jun N-terminal kinase (JNK) and signaling cascades downstream of Ras. Upon T69/T71 phosphorylation; ATF2 interacts with other AP1 proteins and translocate to the nucleus to regulate the expression of hundreds of genes.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr71 of human phospho ATF2
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg