Phospho-S6 Ribosomal Protein (Ser235/236) (Clone: R3A2) rabbit mAb
Produktgrößen
20 µl
£631,00
12-4036-20UL
200 µl
£1021,00
12-4036-200UL
Über dieses Produkt
- SKU:
- 12-4036
- Zusätzliche Namen:
- 40S ribosomal protein S6; Phosphoprotein NP33; Small ribosomal subunit protein eS6; RPS6
- translate.label.attr.clone:
- S6S235S236-R3A2
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Ribosomal protein S6 kinase is one of two parallel signaling pathways downstream of mTOR; with the other being 4E-BP1. mTOR phosphorylates and activates S6 kinase; which then phosphorylates ribosomal protein S6. The pathway regulates cell growth and cell cycle progression. The identified phosphorylation sites of S6 are Ser235; Ser236; Ser240; Ser244; and Ser247; which are evolutionarily conserved in higher eukaryotes. Ser236 has been proposed as the primary phosphorylation site. Studies using S6 knockin mice; where all five phosphorylation site serine residues are replaced by alanine; have provided extensive detail on S6 function. These studies support the role phosphorylated S6 plays in regulation of cell size; glucose homeostasis; and protein synthesis.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser235/236 of human phospho S6 Ribosomal Protein
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
