Phospho-p53 (Ser15) (Clone: 1C11) rabbit mAb
Produktgrößen
20 µl
£631,00
12-4034-20UL
200 µl
£1021,00
12-4034-200UL
Über dieses Produkt
- SKU:
- 12-4034
- Zusätzliche Namen:
- Cellular tumor antigen p53; Tumor suppressor p53; TP53
- translate.label.attr.clone:
- P53S15-1C11
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- p53 is one of the most highly connected nodes in the signal transduction network in the cell; playing a major role in basic cellular functions. p53 is the first tumor-suppressor gene to be identified; and this gene atypically functions in most human cancers. p53 inactivation in these cancers can prevent formation of homo-tetramers; increase p53 degradation; sequester p53 outside the nucleus; or prevent DNA binding and downstream gene activation. DNA damage is one of the most extensively studied p53 activation mechanism. p53 phosphorylation at the N-terminus decreases affinity for MDM2; preventing p53 degradation and leading to excess accumulation. Phosphorylation at the carboxy terminus of p53 enhances DNA binding.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser15 of human phospho p53.
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
