Phospho-Btk (Tyr223) (Clone: B4) rabbit mAb FITC conjugate
Produktgrößen
10 Tests
£532,00
12-4031-10TESTS
100 Tests
£792,00
12-4031-100TESTS
Über dieses Produkt
- SKU:
- 12-4031
- Zusätzliche Namen:
- Bruton tyrosine kinase; Tyrosine-protein kinase BTK; Agammaglobulinemia tyrosine kinase; ATK; AGMX1; B-cell progenitor kinase; BPK
- translate.label.attr.clone:
- BtkY223-B4
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- Btk is a major node in the B-cell receptor signaling pathway; where it regulates B cell maturation; activation; survival; differentiation; and proliferation. Btk is activated by Src family kinases; including Lyn; which phosphorylates Btk at Tyr551. Upon phosphorylation at this site; Btk is recruited to the plasma membrane where autophosphorylation at Tyr223 occurs. The Btk signaling pathway is a major target of small molecule inhibitors for B-cell lymphoma; autoimmune diseases; and non-Hodgkin's lymphomas. These inhibitors either form a covalent bond at Cys481 in the ATP-binding site or serve as reversible inhibitors that bind the SH3 pocket and stabilize inactive Btk.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Tyr223 of human phospho Btk
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg